Invention Grant
- Patent Title: Detection of clusters of magnetic particles
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Application No.: US14125618Application Date: 2012-06-18
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Publication No.: US10036729B2Publication Date: 2018-07-31
- Inventor: Andrea Ranzoni , Menno Willem Jose Prins
- Applicant: Andrea Ranzoni , Menno Willem Jose Prins
- Applicant Address: NL Eindhoven
- Assignee: KONINKLIJKE PHILIPS N.V.
- Current Assignee: KONINKLIJKE PHILIPS N.V.
- Current Assignee Address: NL Eindhoven
- Priority: EP11172070 20110630
- International Application: PCT/IB2012/053051 WO 20120618
- International Announcement: WO2013/001400 WO 20130103
- Main IPC: G01N33/553
- IPC: G01N33/553 ; G01N27/74 ; G01N21/17 ; G01N21/51

Abstract:
The invention relates to a method and a sensor device (100) for the detection of clusters (C) of magnetic particles (MP) in a sample volume (111), particularly of clusters (C) consisting of two magnetic particles (MP) with different binding sites that are bound to a target molecule in a sandwich configuration. Output light (L2) originating from an interaction of input light (L1) with clusters (C) of magnetic particles (MP) is detected. Moreover, the magnetic particles (MP, C) are actuated by a magnetic actuation field (B), wherein said actuation is at least once interrupted by a pause. In this way a high output signal can be achieved that properly reflects the amount of specifically bound clusters (C).
Public/Granted literature
- US20140120632A1 DETECTION OF CLUSTERS OF MAGNETIC PARTICLES Public/Granted day:2014-05-01
Information query
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