Disclosed is a high voltage power system with enable control, comprising a high voltage start-up circuit, a PWM control module, and a driving module; the high voltage start-up circuit comprises a first transistor, a third transistor, a fourth transistor, a resistor, a diode, a VDD detection unit and an I/O interface unit; the high voltage start-up circuit is controlled by an input of a pin EN; when the pin EN is set, the high voltage start-up circuit stops working; the power system is shut off and doesn't restart, and enters a zero standby state; when the pin EN is reset, the high voltage start-up circuit restores to work, and the power system restarts and enters a normal working state. The power system having the high voltage start-up circuit with enable control has characteristics that the standby input power consumption and standby input current are both close to zero.