The present invention relates to a beverage machine with a rotatable brew chamber, and more particularly, to a beverage machine with a rotatable brew chamber wherein the brew chamber is moved upwardly and downwardly and rotated forwardly and backwardly by means of an operation of a lever and high pressure air is supplied to a water outlet pipe connecting a temperature conversion tank and the brew chamber with each other, thus completely discharging the liquid remaining in the water outlet pipe. According to the present invention, the brew chamber can be open or closed by means of one time operation of the lever, thus allowing a cartridge to be easily detachably mounted therein.