Invention Grant
- Patent Title: Use of delta tocopherol for the treatment of lysosomal storage disorders
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Application No.: US15239753Application Date: 2016-08-17
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Publication No.: US10039741B2Publication Date: 2018-08-07
- Inventor: Wei Zheng , Juan Jose Marugan , Ke Liu , Noel Terrence Southall , Christopher P. Austin
- Applicant: The United States of America, as represented by the Secretary, Dept. of Health & Human Services
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services
- Current Assignee Address: US DC Washington
- Main IPC: A61K31/355
- IPC: A61K31/355 ; A61K31/36 ; A61K31/496 ; A61K31/724 ; A61K36/185 ; A61K45/06

Abstract:
This disclosure relates generally to the treatment of lysosomal storage disorders. Specifically, the disclosure relates to a novel use of δ tocopherol in the treatment of diseases and conditions related to lysosomal storage disorders. Included in the present disclosure is a method for the modulation of cholesterol recycling. Further, the disclosure relates to conditions such as Niemann-Pick type C disease, Farber disease, Niemann-Pick type A disease, Wolman disease and Tay Sachs disease. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of δ tocopherol. Further included in the present disclosure is a method for treating lysosomal storage disorders comprising the administration of δ tocopherol in combination with cyclodextrin to a patient in need thereof.
Public/Granted literature
- US20170027903A1 USE OF DELTA TOCOPHEROL FOR THE TREATMENT OF LYSOSOMAL STORAGE DISORDERS Public/Granted day:2017-02-02
Information query
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