- Patent Title: Reducing memory loss in mammals suffering from alzheimer's disease
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Application No.: US14901620Application Date: 2014-07-15
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Publication No.: US10039756B2Publication Date: 2018-08-07
- Inventor: Gong Chen , Zheng Wu , Ziyuan Guo
- Applicant: The Penn State Research Foundation
- Applicant Address: US PA University Park
- Assignee: The Penn State Research Foundation
- Current Assignee: The Penn State Research Foundation
- Current Assignee Address: US PA University Park
- Agency: Fish & Richardson P.C.
- International Application: PCT/US2014/046723 WO 20140715
- International Announcement: WO2015/013069 WO 20150129
- Main IPC: A61P25/28
- IPC: A61P25/28 ; A61K31/455 ; A61K45/06 ; A61K31/445 ; A61K31/454 ; A61K31/551 ; A61K51/04 ; G01N33/94 ; A61K9/00 ; A61K31/5517 ; A61K31/7088 ; A61K51/10
Abstract:
The disclosure relates to methods and compositions for reducing memory loss. Specifically, methods of using inhibitors of GAT-3 polypeptide activity to reduce memory loss in mammals suffering from Alzheimer's disease (AD) are provided. Further provided are methods for identifying a mammal as having AD by detecting the presence of an elevated level of gamma-aminobutyric acid (GABA) within a mammal's brain.
Public/Granted literature
- US20160317521A1 REDUCING MEMORY LOSS IN MAMMALS SUFFERING FROM ALZHEIMER'S DISEASE Public/Granted day:2016-11-03
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