A deodorant stick drug delivery system has one or more hydrophilic carriers, water, one or more gelling agents, an active ingredient, and a solvent. The active ingredient may be cannabinoids, nicotine, caffeine, vitamins, insulin and tetrahydrocannabinol. The solvent may be, for example dimethyl sulfoxide, benzyl alcohol, and water. The solvent may be non-mutagenic, and/or non-teratogenic. Nanoparticles may be used that enable the active ingredient to pass through endothelial tissue, and microparticles may be used to create microabrasions in the skin and increase absobancy. Finally, a permeability compound may be used to increase permeability across dermal layers.