Invention Grant
- Patent Title: Siderophore-based immunization against gram-negative bacteria
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Application No.: US14700397Application Date: 2015-04-30
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Publication No.: US10039816B2Publication Date: 2018-08-07
- Inventor: Elizabeth Marie Nolan , Phoom Chairatana , Manuela Raffatellu , Martina Sassone Corsi , Araceli Perez-Lopez
- Applicant: Massachusetts Institute of Technology , The Regents of the University of California
- Applicant Address: US MA Cambridge US CA Oakland
- Assignee: Massachusetts Institute of Technology,The Regents of the University of California
- Current Assignee: Massachusetts Institute of Technology,The Regents of the University of California
- Current Assignee Address: US MA Cambridge US CA Oakland
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: A61K39/12
- IPC: A61K39/12 ; G01N33/00 ; A61K39/02 ; A61K39/00 ; C07K19/00 ; G01N33/569 ; A61K47/64
Abstract:
The present invention provides novel enterobactin-carrier protein conjugates and salmochelin-carrier protein conjugates, such as compounds of Formula (I), and salts thereof. The present invention also provides compositions, kits, and methods that involve the compounds of Formula (I) and are useful in inducing an immune response, treating a bacterial infection and/or inflammatory bowel disease in a subject, preventing a bacterial infection and/or inflammatory bowel disease in a subject, or inhibiting the growth of or killing a bacterium.
Public/Granted literature
- US20160022794A1 SIDEROPHORE-BASED IMMUNIZATION AGAINST GRAM-NEGATIVE BACTERIA Public/Granted day:2016-01-28
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