A syringe sealing assembly includes a stopper coupling and a plunger coupling. The stopper coupling is adaptable to attach to a syringe stopper. The plunger coupling is releasably attachable to the stopper coupling. The stopper coupling is further adaptable to fit within a syringe barrel and to seal the interior of the syringe barrel from the external environment in cooperation with the syringe stopper. The plunger coupling is adaptable to attach to a syringe plunger. The plunger coupling is further adaptable to be received within a syringe barrel when the plunger coupling is attached to the stopper coupling. The plunger coupling is further adaptable to be withdrawn from the syringe barrel while the stopper coupling remains in the syringe barrel when the plunger coupling is detached from the stopper coupling.