Invention Grant
- Patent Title: Formulation for anti-α4β7 antibody
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Application No.: US14114835Application Date: 2012-05-02
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Publication No.: US10040855B2Publication Date: 2018-08-07
- Inventor: Willow Diluzio , Phoung M. Nguyen , Csanad M. Varga , Vaithianathan Palaniappan , Jason Brown
- Applicant: Willow Diluzio , Phoung M. Nguyen , Csanad M. Varga , Vaithianathan Palaniappan , Jason Brown
- Applicant Address: US MA Cambridge
- Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee: Millennium Pharmaceuticals, Inc.
- Current Assignee Address: US MA Cambridge
- Agency: Womble Bond Dickinson (US) LLP
- Agent Cristin H. Cowles
- International Application: PCT/US2012/036069 WO 20120502
- International Announcement: WO2012/151247 WO 20121108
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/28 ; A61K9/00 ; A61K47/12 ; A61K47/14 ; A61K47/18 ; A61K47/26 ; A61K39/00
Abstract:
Antibody formulations are described comprising a mixture of an anti-α4β7 antibody, an antioxidant or chelator, and at least one free amino acid. The disclosed formulations may have improved stability, reduced aggregate formation, or both. The present invention further provides a safe dosing regimen of these antibody formulations that is easy to follow, and which results in a therapeutically effective amount of the anti-α4β7 antibody in vivo.
Public/Granted literature
- US20140341885A1 FORMULATION FOR ANTI-ALPHA4BETA7 ANTIBODY Public/Granted day:2014-11-20
Information query
