Invention Grant
- Patent Title: Antibodies targeted against LOXL-2 for the treatment of collagen-associated pathologies
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Application No.: US15328036Application Date: 2014-07-24
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Publication No.: US10040868B2Publication Date: 2018-08-07
- Inventor: Irit Sagi , Moran Grossman , Nir Ben-Chetrit
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2014/050678 WO 20140724
- International Announcement: WO2016/012993 WO 20160128
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/395 ; C07K16/40 ; A61K45/06 ; A61K33/24
Abstract:
An article of manufacture is disclosed which comprises at least two active agents, wherein a first of the two active agents comprises an anti-cancer agent or an antifibrotic agent and a second of the at least two active agents downregulates the activity and/or expression of lysyl-oxidase like protein-2 (LOXL-2) and which is capable of altering the structure of the extracellular matrix.
Public/Granted literature
- US20170210823A1 ANTIBODIES TARGETED AGAINST LOXL-2 FOR THE TREATMENT OF COLLAGEN-ASSOCIATED PATHOLOGIES Public/Granted day:2017-07-27
Information query
