Invention Grant
- Patent Title: Rationally-designed single-chain meganucleases with non-palindromic recognition sequences
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Application No.: US15132941Application Date: 2016-04-19
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Publication No.: US10041053B2Publication Date: 2018-08-07
- Inventor: James Jefferson Smith , Derek Jantz
- Applicant: Precision BioSciences, Inc.
- Applicant Address: US NC Durham
- Assignee: Precision BioSciences, Inc.
- Current Assignee: Precision BioSciences, Inc.
- Current Assignee Address: US NC Durham
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N9/22
- IPC: C12N9/22 ; C12N15/90 ; C12N9/16 ; C12N15/85

Abstract:
Disclosed are rationally-designed, non-naturally-occurring meganucleases in which a pair of enzyme subunits having specificity for different recognition sequence half-sites are joined into a single polypeptide to form a functional heterodimer with a non-palindromic recognition sequence. The invention also relates to methods of producing such meganucleases, and methods of producing recombinant nucleic acids and organisms using such meganucleases.
Public/Granted literature
- US20160222417A1 RATIONALLY-DESIGNED SINGLE-CHAIN MEGANUCLEASES WITH NON-PALINDROMIC RECOGNITION SEQUENCES Public/Granted day:2016-08-04
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