Invention Grant
- Patent Title: Reduced size self-delivering RNAi compounds
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Application No.: US13069780Application Date: 2011-03-23
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Publication No.: US10041073B2Publication Date: 2018-08-07
- Inventor: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
- Applicant: Anastasia Khvorova , William Salomon , Joanne Kamens , Dmitry Samarsky , Tod M. Woolf , James Cardia
- Applicant Address: US MA Marlborough
- Assignee: RXi Pharmaceuticals Corporation
- Current Assignee: RXi Pharmaceuticals Corporation
- Current Assignee Address: US MA Marlborough
- Agency: Wolf, Greenfield & Sacks, P.C.
- Main IPC: C12N15/113
- IPC: C12N15/113 ; C12N15/11
Abstract:
The present invention relates to RNAi constructs with minimal double-stranded regions, and their use in gene silencing. RNAi constructs associated with the invention include a double stranded region of 8-14 nucleotides and a variety of chemical modifications, and are highly effective in gene silencing. The RNAi constructs may be, for instance, miRNA constructs that are miRNA modulators.
Public/Granted literature
- US20110263680A1 REDUCED SIZE SELF-DELIVERING RNAI COMPOUNDS Public/Granted day:2011-10-27
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