Invention Grant
- Patent Title: Biomarkers of mineralocorticoid receptor activation
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Application No.: US15188198Application Date: 2016-06-21
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Publication No.: US10041122B2Publication Date: 2018-08-07
- Inventor: Frederic Jaisser , Nicolette Farman , Yannis Sainte-Marie , Celine Latouche , Marja Steenman
- Applicant: INSERM (Institut National de la Sante et de la Recherche Medicale)
- Applicant Address: FR Paris
- Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
- Current Assignee: INSERM (INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE)
- Current Assignee Address: FR Paris
- Agency: W&C IP
- Priority: EP08305728 20081024
- Main IPC: C12Q1/68
- IPC: C12Q1/68 ; G01N33/68 ; C12Q1/6883
Abstract:
The present invention relates to the use of Neutrophil Gelatinase-Associated Lipocalin (NGAL) and/or SERPINA3 as biomarkers of the Mineralocorticoid Receptor (MR) activation in a patient. More particularly, the present invention relates to a method for predicting the responsiveness of a patient to a treatment with a MR antagonist or an aldosterone synthase inhibitor, said method comprising determining in a biological sample obtained from said patient the expression level of the NGAL gene and/or of the SERPINA3 gene.
Public/Granted literature
- US20160362744A1 Biomarkers of Mineralocorticoid Receptor Activation Public/Granted day:2016-12-15
Information query
