Systems and methods are disclosed for hash level load balancing for removal of duplicate network packets to form deduplicated packet streams. Hash values for input packets are used in part to select deduplication engines to receive hash data associated with received input packets, and this hash data is then forwarded to the selected deduplication engines for deduplication processing. The hash level load balancing reduces bandwidth requirements within the deduplication processing as compared to prior packet-based load balancing solutions for deduplication systems. Additional embodiments utilize port identifiers in addition to hash values to allow for increased flexibility in deduplication of packets from multiple input ports.