Innovations in encoding of video pictures in a high-resolution chroma sampling format (such as YUV 4:4:4) using a video encoder operating on coded pictures in a low-resolution chroma sampling format (such as YUV 4:2:0) are presented. For example, according to a set of decision rules, high chroma resolution details are selectively encoded on a region-by-region basis such that increases in bit rate (due to encoding of sample values for the high chroma resolution details) happen when and where corresponding increases in chroma resolution are likely to improve quality in noticeable ways. In this way, available encoders operating on coded pictures in the low-resolution chroma sampling format can be effectively used to provide high chroma resolution details.