Invention Grant
- Patent Title: Methods of purifying antibodies
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Application No.: US13655955Application Date: 2012-10-19
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Publication No.: US10047144B2Publication Date: 2018-08-14
- Inventor: Greg Elson , Nicolas Fouque , Jean-Francois Depoisier , Nicolas Fischer , Giovanni Magistrelli
- Applicant: NovImmune S.A.
- Applicant Address: CH Geneva
- Assignee: NovImmune SA
- Current Assignee: NovImmune SA
- Current Assignee Address: CH Geneva
- Agency: Cooley LLP
- Agent Ivor R. Elrifi; Cynthia Kozakiewicz
- Main IPC: C07K16/46
- IPC: C07K16/46 ; C07K16/00 ; C07K16/24 ; C07K16/28

Abstract:
The invention provides methods of purifying antibodies using various antibody-specific purification media to rapidly and efficiently separate mixtures of antibodies, antibody fragments and/or antibody components to isolate a desired antibody product from the mixture. The invention relates to the purification of bispecific monoclonal antibodies carrying a different specificity for each binding site of the immunoglobulin molecule, e.g., antibodies composed of a single heavy chain and two different light chains, one containing a Kappa constant domain and the other a Lambda constant domain, including antibodies of different specificities that share a common heavy chain. The invention also provides the methods of efficiently purifying intact antibodies by separating the intact antibody from non-intact antibodies including free light chains.
Public/Granted literature
- US20130317200A1 Methods of Purifying Antibodies Public/Granted day:2013-11-28
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