A tobacco smoking mixture including an ammonia-release compound adapted to be formed into a lit-end cigarette is provided. The ammonia-release compound is incorporated in or on tobacco cut filler in an amount effective to reduce the cytotoxicity, and/or selective smoke constituents of cigarette smoke. Exemplary ammonia-release compounds include ammonium acetate, ammonium hydroxide, hexammine cobalt (III) chloride, hexammine cobalt (III) acetate, and combinations thereof. The ammonia-release compounds can release ammonia at temperatures between about 60° C. and about 400° C. Ammonia-release compounds can be combined with additives, such as glycerine, cobalt acetate, copper (II) acetate, zinc acetate, other metal salts or combinations thereof, to further reduce the cytotoxicity of cigarette smoke.