A hand perspiration removal device has a base which includes top and bottom surfaces, a perspiration absorbing pad which is removably attached to the top surface, and an arrangement for securing the base to a part of a user's body. The bottom surface of the base has a concave configuration which extends from a first side of the base to a second, opposite side of the base such that the bottom surface is configured to conform to the part of the user's body to which the device is secured.