A method of manufacturing a two-piece food can having improved corrosion resistance is provided, wherein the two-piece food can using a metal sheet coated with a thermoplastic resin and having annular uneven beads and/or a bottom rim. After forming a bottomed cylindrical can body by drawing and ironing, by heating at a temperature higher than the melting temperature of the thermoplastic resin for a predetermined time before forming uneven beads and/or a bottom rim to the can body and quenching within a predetermined time after heating, the inner resin coating hardly peel off during the following formation of uneven beads and/or the bottom rim. As a result, a two-piece food can having excellent corrosion resistance may be obtained.