A condition monitoring system (CMS) for vehicle bearing units, including at least one condition monitoring unit (CMU) for measuring at least one operating parameter of one bearing unit and a control unit for receiving and processing signals from the CMU. The control unit is configured to activate/deactivate the CMU(s) upon reaching at least one predetermined waypoint stored in a waypoint memory of the control unit. The CMS can be equipped with a waypoint setting unit for setting the at least one waypoint at which the CMU(s) shall be activated/deactivated and to store the waypoint in the waypoint memory. The waypoint setting unit processes route data includes data on at least a curviness of at least one route intended for vehicle travel. The processing includes extracting at least one route section within the curviness of the route within a predetermined range and setting the waypoint(s) within the extracted route section.