Invention Grant
- Patent Title: Neprilysin inhibitors
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Application No.: US15806722Application Date: 2017-11-08
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Publication No.: US10053417B2Publication Date: 2018-08-21
- Inventor: Erik Fenster , Melissa Fleury , Adam D. Hughes
- Applicant: THERAVANCE BIOPHARMA R&D IP, LLC
- Applicant Address: US CA South San Francisco
- Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee: THERAVANCE BIOPHARMA R&D IP, LLC
- Current Assignee Address: US CA South San Francisco
- Agent Jeffrey A. Hagenah; Wendy Petka
- Main IPC: A61K31/40
- IPC: A61K31/40 ; A61K31/42 ; A61K31/44 ; A61K31/197 ; A61K31/397 ; A61K31/5375 ; C07D205/04 ; C07D207/09 ; C07D207/14 ; C07D213/56 ; C07C235/34 ; C07D261/04 ; C07D295/32 ; C07C243/38 ; A61K31/341 ; A61K31/4409 ; C07D213/86 ; C07D213/87 ; C07C235/80 ; A61K31/4406 ; A61K31/192 ; C07D213/65 ; A61K45/06 ; A61K31/495 ; A61K31/4015 ; C07D307/68 ; C07D213/61 ; C07D211/62 ; C07D211/60 ; C07D211/48 ; C07D211/46 ; C07D211/42 ; C07D211/38 ; C07D211/22 ; C07C243/32 ; C07C243/24 ; C07D493/10 ; C07D207/16 ; C07D207/12 ; C07D207/08 ; C07D265/30 ; C07C235/78 ; C07C235/74 ; C07C235/20 ; C07C235/12 ; C07C233/56 ; C07D261/02 ; C07D239/36 ; C07D405/06 ; C07D401/04 ; C07D233/06 ; C07D309/08 ; C07C259/04 ; C07D213/75 ; C07D491/107
Abstract:
In one aspect, the invention relates to compounds having the formula: where R1-R5 and X are as defined in the specification, or a pharmaceutically acceptable salt thereof. These compounds have neprilysin inhibition activity. In another aspect, the invention relates to pharmaceutical compositions comprising such compounds; methods of using such compounds; and processes and intermediates for preparing such compounds.
Public/Granted literature
- US20180194718A1 NEPRILYSIN INHIBITORS Public/Granted day:2018-07-12
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