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US10053452B2 Crystalline forms of N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine salts and uses thereof 有权

  • Patent Title: Crystalline forms of N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine salts and uses thereof
  • Application No.: US15101373
    Application Date: 2014-11-25
  • Publication No.: US10053452B2
    Publication Date: 2018-08-21
  • Inventor: Mary Chaves , Matthew Bio , Matthew Peterson
  • Applicant: AMGEN INC.
  • Applicant Address: US CA Thousand Oaks
  • Assignee: AMGEN INC.
  • Current Assignee: AMGEN INC.
  • Current Assignee Address: US CA Thousand Oaks
  • Agent Richard V. Person
  • International Application: PCT/US2014/067385 WO 20141125
  • International Announcement: WO2015/084649 WO 20150611
  • Main IPC: C07D409/14
  • IPC: C07D409/14 ;  A61K31/506 ;  C07C309/04 ;  C07C309/30
Crystalline forms of N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine salts and uses thereof
Abstract:
The present invention relates to crystalline forms and co-crystal forms of pharmaceutically acceptable salts of the compound, N-(4-((3-(2-amino-4-pyrimidinyl)-2-pyridinyl)oxy)phenyl)-4-(4-methyl-2-thienyl)-1-phthalazinamine (AMG 900, and pharmaceutical compositions comprising said crystalline and co-crystal forms thereof. The invention further provides uses of the crystalline forms and compositions, to treat cancer, including various types of solid tumors and hematologic cancer including myeloma and leukemia.
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