![Process for the preparation of tert-butyl 4-((2S ,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof](/docs/US/2018-08-21/US10053460B2/abs.jpg.600x600.jpg)
- Patent Title: Process for the preparation of tert-butyl 4-((2S ,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof
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Application No.: US15532788Application Date: 2015-11-30
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Publication No.: US10053460B2Publication Date: 2018-08-21
- Inventor: Zhijian Liu , Nobuyoshi Yasuda , Lu Yang , Artis Klapars , Kevin R. Campos , Mikhail Reibarkh
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Patricia A. Shatynski; John C. Todaro
- International Application: PCT/US2015/062884 WO 20151130
- International Announcement: WO2016/089718 WO 20160609
- Main IPC: C07D471/08
- IPC: C07D471/08 ; C07F7/02 ; C07F7/10 ; C07F7/18
![Process for the preparation of tert-butyl 4-((2S ,5R)-6-(benzyloxy)-7-oxo-1,6-diazabicyclo[3.2.1]octane-2-carboxamido)piperidine-1-carboxylate and analogs thereof](/abs-image/US/2018/08/21/US10053460B2/abs.jpg.150x150.jpg)
Abstract:
The present invention relates to processes for preparing compounds of Formula I. Such compounds include interme-diates in the manufacture of 7-oxo-1,6-diazabicyclo[3.2.1 ]octane-2-carboxamide beta-lactamase inhibitors such as (2S,5R)-7-oxo-N-5 piperidin-4-yl-6-(sulfoxy)-1,6-diazabicyclo[3.2.1]octane-2-carboxamide. The present invention also relates to novel intermediates formed i these processes. The present invention relates to a process for preparing a compound of Formula I or a pharmaceutically acceptable salt thereof.
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