Invention Grant
- Patent Title: P2X7 modulators
-
Application No.: US15375774Application Date: 2016-12-12
-
Publication No.: US10053462B2Publication Date: 2018-08-21
- Inventor: Michael A. Letavic , Dale A. Rudolph
- Applicant: Jansssen Pharmaceutica NV
- Applicant Address: BE Beerse
- Assignee: Janssen Pharmaceutica NV
- Current Assignee: Janssen Pharmaceutica NV
- Current Assignee Address: BE Beerse
- Agent Thomas J. Dodd
- Main IPC: C07D498/18
- IPC: C07D498/18 ; C07D487/18 ; C07D471/18

Abstract:
The present invention is directed to a compound of Formula (I): wherein: n is an integer from 0-1; X is CH2 when n is 0, or X is CH2 or oxygen when n is 1; R1 is phenyl or pyridinyl, wherein the phenyl or pyridinyl is optionally substituted with from 1 to 4 substituents independently selected from halogen and alkyl; and R2 is phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl, wherein the phenyl, pyridinyl, pyrazinyl, pyradizinyl, pyrimidinyl, pyrrolyl, pyrazolyl, thiazolyl or thiophenyl is optionally substituted with from 1 to 2 substituents independently selected from the group consisting of halogen, alkyl, hydroxy and alkoxy. The invention also relates to pharmaceutical compositions comprising compounds of Formula (I). Methods of making and using the compounds of Formula (I) are also within the scope of the invention.
Public/Granted literature
- US20170088550A1 P2X7 MODULATORS Public/Granted day:2017-03-30
Information query