Distributed communications systems (DCSs) supporting configuring or reconfiguring the distribution of MIMO communications streams to designated remote units in the DCS to provide interleaved MIMO cell bonding of remote units are disclosed. In one example, the DCS includes different physical layers that are maintained from the central unit to the remote units. In this manner, the central unit can be configured or reconfigured to distribute separate MIMO communications streams to the desired physical layers in the DCS to support distributing MIMO communications streams to the desired remote units to provide the desired interleaved MIMO communications services. In this manner, interleaved MIMO communications services can be configured for a DCS using an existing infrastructure of remote units having substantially non-overlapping remote coverage areas, by directing the MIMO communications streams over the configured physical layers to be provided to the desired remote units to facilitate interleaved MIMO cell bonding of remote units.