Methods, devices, and computer-readable media for wireless communication may involve techniques for managing multi-user (MU) operation when a device in a wireless network has coexisting radios. Such techniques may involve identifying a change in a multiple radio access technology (RAT) coexistence status of a first device, e.g., a change between a coexistence status that is not disruptive to MU communications and one that is disruptive. For a device communicating with a network using Wi-Fi, the change in the multiple RAT coexistence status may indicate a change between inactive Bluetooth (BT) communications and active BT communications concurrent with Wi-Fi communications. Based at least in part on the identified change in the multiple RAT coexistence status, a MU communications operation at a second device may be adjusted, for example, by disabling MU communication between the first and second devices over a first RAT when the first device changes to a coexistence status that may disrupt MU communications.