This document describes assessment of human physiological systems. Various noninvasive sensors can be used to detect vitals and other parameters and combined with mathematical models to assess the functional state of physiological systems. Conventional techniques can use invasive sensors to monitor cardiac pressures and volumes, along with pressure transit to quantify cardiovascular health. While known to be effective these invasive techniques often require surgery and are resource intensive limiting their use to cases where the risks and costs are of clear immediate benefit. In contrast, noninvasive health monitors present little if any risk and are easy to use. Further, the techniques described herein can determine trends in a person's cardiovascular health. With these trends, a person can know if the effort they expend to improve heart health actually makes a difference. Further, negative trends can be found that can spur people to improve their health or get medical attention.