- Patent Title: Treatment and prevention of cardiovascular disease and thrombosis
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Application No.: US15605437Application Date: 2017-05-25
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Publication No.: US10064830B2Publication Date: 2018-09-04
- Inventor: Stanley L. Hazen , Bruce Levison , Zeneng Wang
- Applicant: The Cleveland Clinic Foundation
- Agency: Casimir Jones, S.C.
- Agent Jason Bond
- Main IPC: A61K31/66
- IPC: A61K31/66 ; A61K31/10 ; A61K31/22 ; A61K31/045 ; A61K45/06 ; A61K31/205 ; A61K31/695 ; A23L2/52 ; A61K31/133 ; A61K31/663 ; A23L33/10 ; A61K31/19
Abstract:
Provided herein are compositions for the treatment and/or prevention of cardiovascular disease (CVD), and methods of application and use thereof. In particular, the present invention provides treatment and/or prevention of cardiovascular disease with compounds that inhibit the production of TMA in the gut, such as 3,3-dimethyl-1-butanol (DMB) or other compounds represented by Formula I or as shown in FIGS. 20-23.
Public/Granted literature
- US20170258740A1 TREATMENT AND PREVENTION OF CARDIOVASCULAR DISEASE AND THROMBOSIS Public/Granted day:2017-09-14
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