Invention Grant
- Patent Title: Use of metformin in combination with a glucokinase activator and compositions comprising metformin and a glucokinase activator
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Application No.: US15687824Application Date: 2017-08-28
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Publication No.: US10064846B2Publication Date: 2018-09-04
- Inventor: Adnan M. M. Mjalli , Maria Carmen Valcarce Lopez
- Applicant: vTv Therapeutics LLC
- Applicant Address: US NC High Point
- Assignee: vTv Therapeutics LLC
- Current Assignee: vTv Therapeutics LLC
- Current Assignee Address: US NC High Point
- Agent Samuel B. Rollins
- Main IPC: A61K31/155
- IPC: A61K31/155 ; A61K31/425 ; A61K31/426 ; C07D277/54
Abstract:
The present invention provides uses of a glucokinase activator in combination with metformin. Uses include treating type 2 diabetes, lowering blood glucose, improving insulin sensitivity, enhancing phosphorylation of glucose, and improving the therapeutic effectiveness of metformin. The invention also provides pharmaceutical compositions that comprise a GK activator and metformin. The invention also provides a salt formed between metformin and a GK activator.
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