Invention Grant
- Patent Title: Metabolic gene, enzyme, and flux targets for cancer therapy
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Application No.: US13809333Application Date: 2011-07-08
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Publication No.: US10064885B2Publication Date: 2018-09-04
- Inventor: Gregory Stephanopoulos , Christian M. Metallo , Joanne K. Kelleher , Othon Iliopoulos , Paulo Alexandre da Costa Gameiro Guerreiro
- Applicant: Gregory Stephanopoulos , Christian M. Metallo , Joanne K. Kelleher , Othon Iliopoulos , Paulo Alexandre da Costa Gameiro Guerreiro
- Applicant Address: US MA Cambridge US MA Boston
- Assignee: Massachusetts Institute of Technology,The General Hospital Corporation
- Current Assignee: Massachusetts Institute of Technology,The General Hospital Corporation
- Current Assignee Address: US MA Cambridge US MA Boston
- Agency: Wolf, Greenfield & Sacks, P.C.
- International Application: PCT/US2011/043324 WO 20110708
- International Announcement: WO2012/006506 WO 20120112
- Main IPC: C12N15/11
- IPC: C12N15/11 ; A61K31/713 ; C12N15/113 ; A61K31/194 ; A61K31/433 ; A61K31/655 ; A61K45/06
Abstract:
A novel pathway in cancer cell metabolism is identified. Targeting of any gene, protein, or enzyme that modulates activity or flux through this pathway, including, but not limited to IDH1, isocitrate dehydrogenase 2 (IDH2), aconitase 1 (ACO1), aconitase 2 (ACO2), glutaminase (GLS), glutamate dehydrogenase (GDH) and transaminase, provides effective means of inhibiting tumor growth.
Public/Granted literature
- US20130331432A1 METABOLIC GENE, ENZYME, AND FLUX TARGETS FOR CANCER THERAPY Public/Granted day:2013-12-12
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