Invention Grant
- Patent Title: Recombinant rift valley fever (RVF) viruses and methods of use
-
Application No.: US15227321Application Date: 2016-08-03
-
Publication No.: US10064933B2Publication Date: 2018-09-04
- Inventor: Brian H. Bird , Cesar G. Albarino , Stuart T. Nichol , Thomas G. Ksiazek
- Applicant: The United States of America as represented by the Secretary of the Dept. of Health and Human Services, Centers for Disease Control and Prevention
- Applicant Address: US DC Washington
- Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee: The United States of America as represented by the Secretary of the Department of Health and Human Services, Centers for Disease Control and Prevention
- Current Assignee Address: US DC Washington
- Agency: Klarquist Sparkman, LLP
- Main IPC: C12N7/00
- IPC: C12N7/00 ; A61K39/12 ; A61K35/76 ; A61K39/00
Abstract:
Described herein are recombinant RVF viruses comprising deletions in one or more viral virulence genes, such as NSs and NSm. The recombinant RVF viruses, generated using a plasmid-based reverse genetics system, can be used as vaccines to prevent infection of RVF virus in livestock and humans. As described herein, the recombinant RVF viruses grow to high titers, provide protective immunity following a single injection and allow for the differentiation between vaccinated animals and animals infected with wild-type RVF virus.
Public/Granted literature
- US20160331827A1 RECOMBINANT RIFT VALLEY FEVER (RVF) VIRUSES AND METHODS OF USE Public/Granted day:2016-11-17
Information query
