- Patent Title: Chromene derivatives and their analogs as Wnt pathway antagonists
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Application No.: US15158733Application Date: 2016-05-19
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Publication No.: US10065939B2Publication Date: 2018-09-04
- Inventor: Michael Boutros , Rajendra-Prasad Maskey , Corinna Koch , Florian Fuchs , Sandra Steinbrink , Daniel Gilbert
- Applicant: Deutsches Krebsforschungszentrum , Ruprecht-Karls-Universität Heidelberg
- Applicant Address: DE Heidelberg DE Heidelberg
- Assignee: Deutsches Krebsforschungszentrum,Ruprecht-Karls-Universität Heidelberg
- Current Assignee: Deutsches Krebsforschungszentrum,Ruprecht-Karls-Universität Heidelberg
- Current Assignee Address: DE Heidelberg DE Heidelberg
- Agency: Clark & Elbing LLP
- Priority: EP10191072 20101112
- Main IPC: C07D311/92
- IPC: C07D311/92 ; C07D311/96 ; C07D413/04 ; C07D491/04 ; C07D493/04 ; C07D311/04 ; C07D491/052

Abstract:
Compounds of formula (IIc); wherein X3 and X4 independently from each other are N or CR8 wherein R8 may be same or different; Y1, Y2, Y3 and Y4 independently from each other are N or CR9 wherein R9 may be same or different and wherein up to 3 of the group Y1, Y2, Y3 and Y4 may be N; their solvates, hydrates, and pharmaceutically acceptable salts, their use for modulating the Wnt signalling pathway activity and their use as a medicament, preferably for the treatment of cancer.
Public/Granted literature
- US20160355496A1 CHROMENE DERIVATIVES AND THEIR ANALOGS AS WNT PATHWAY ANTAGONISTS Public/Granted day:2016-12-08
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