Invention Grant
- Patent Title: Dihydroindolizinone derivative
-
Application No.: US15534247Application Date: 2015-12-09
-
Publication No.: US10065955B2Publication Date: 2018-09-04
- Inventor: Motoyuki Tanaka , Takashi Kondo , Yasuo Hirooka , Taihei Nishiyama , Atsushi Hiramatsu , Tomoyuki Koda , Sho Kouyama
- Applicant: ONO PHARMACEUTICAL CO., LTD.
- Applicant Address: JP Osaka
- Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee: ONO PHARMACEUTICAL CO., LTD.
- Current Assignee Address: JP Osaka
- Agency: Wenderoth, Lind & Ponack, L.L.P.
- Priority: JP2014-249822 20141210; JP2014-263251 20141225; JP2015-046150 20150309; JP2015-160632 20150817
- International Application: PCT/JP2015/084573 WO 20151209
- International Announcement: WO2016/093285 WO 20160616
- Main IPC: C07D471/04
- IPC: C07D471/04 ; C07D487/04 ; A61K9/20 ; A61K31/444 ; A61K31/519

Abstract:
A compound represented by general formula (I) (wherein all symbols are as defined in the description) or a salt, solvate, N-oxide form or prodrug thereof is a potent FXIa inhibitor, has excellent oral absorption properties and kinetics in blood, can exert a potent anti-coagulation activity over a long period of time after being administered orally, and has a discrepancy between the anti-coagulation activity thereof and the CYP-inhibiting activity thereof. Therefore, the compound or the salt, solvate, N-oxide form or prodrug thereof can be used as an efficient prophylactic and/or therapeutic agent for vascular occlusive diseases.
Public/Granted literature
- US20170349580A1 DIHYDROINDOLIZINONE DERIVATIVE Public/Granted day:2017-12-07
Information query