Invention Grant
- Patent Title: Amide derivatives of 1-oxa-4,9-diazaspiro undecane compounds having multimodal activity against pain
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Application No.: US15315095Application Date: 2015-06-02
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Publication No.: US10065971B2Publication Date: 2018-09-04
- Inventor: Marina Virgili-Bernado , Monica Alonso-Xalma , Carlos Alegret-Molina , Carmen Almansa-Rosales , Ramón Merce-Vidal
- Applicant: LABORATORIOS DEL DR. ESTEVE S.A.
- Applicant Address: ES Barcelona
- Assignee: ESTEVE PHARMACEUTICALS S.A.
- Current Assignee: ESTEVE PHARMACEUTICALS S.A.
- Current Assignee Address: ES Barcelona
- Agency: Hueschen and Sage
- Priority: EP14382208 20140602
- International Application: PCT/EP2015/001114 WO 20150602
- International Announcement: WO2015/185208 WO 20151210
- Main IPC: C07D498/10
- IPC: C07D498/10
Abstract:
The present invention relates to compounds having dual pharmacological activity towards both the sigma (σ) receptor, and the μ-opiod receptor and more particularly to diazaspiro undecane compounds having this pharmacological activity, to processes of preparation of such compounds, to pharmaceutical compositions comprising them, and to their use in therapy, in particular for the treatment of pain. wherein Y is n is 1 or 2; q is 1, 2, 3, 4, 5 or 6; X is a bond, —C(O)O—, —C(O)NR8—, —C(O)—, —O— or —C(R4R4′)—; R1 is C(O)R5 or S(O)2R5.
Public/Granted literature
- US20170197984A1 AMIDE DERIVATIVES OF 1-OXA-4,9-DIAZASPIRO UNDECANE COMPOUNDS HAVING MULTIMODAL ACTIVITY AGAINST PAIN Public/Granted day:2017-07-13
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