Invention Grant
- Patent Title: Methods of producing two chain proteins in bacteria
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Application No.: US14934094Application Date: 2015-11-05
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Publication No.: US10066002B2Publication Date: 2018-09-04
- Inventor: James Giulianotti , Dorothea Reilly , Kieran Aurori , Laura C. Simmons
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: GENENTECH, INC.
- Current Assignee: GENENTECH, INC.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison and Foerster LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K14/725 ; C07K16/00 ; C07K16/22 ; C07K16/24 ; C07K16/28 ; C12P21/00 ; C12N15/70 ; A61K39/00 ; C12P21/02 ; C12P21/08
Abstract:
Provided herein are methods of producing a recombinant polypeptide containing two chains, such as an immune mobilizing monoclonal T-cell receptor against cancer (ImmTAC) protein including an alpha chain and a beta chain. In particular, methods are provided for producing heterologous secretory proteins in bacteria through utilization of optimized expression vectors and culture processes.
Public/Granted literature
- US20160159880A1 METHODS OF PRODUCING TWO CHAIN PROTEINS IN BACTERIA Public/Granted day:2016-06-09
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