- Patent Title: Anti CD84 antibodies, compositions comprising same and uses thereof
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Application No.: US15116276Application Date: 2015-02-05
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Publication No.: US10066014B2Publication Date: 2018-09-04
- Inventor: Idit Shachar , Inbal Binsky , Ayelet Marom
- Applicant: Yeda Research and Development Co. Ltd.
- Applicant Address: IL Rehovot
- Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee: Yeda Research and Development Co. Ltd.
- Current Assignee Address: IL Rehovot
- International Application: PCT/IL2015/050133 WO 20150205
- International Announcement: WO2015/118538 WO 20150813
- Main IPC: C07K16/28
- IPC: C07K16/28 ; G01N33/574 ; C07K16/30 ; G01N33/50 ; A61K39/395
Abstract:
An isolated antibody comprising an antigen recognition domain which specifically binds CD84 and (i) down regulates the anti-apoptotic activity of stromal cells on chronic lymphocytic leukemia (CLL) cells; and/or (ii) induces mobilization of CLL cells from the bone marrow. Also provided are antibodies comprising antigen recognition domains comprising complementarity determining regions as indicated and uses thereof.
Public/Granted literature
- US20170260270A1 ANTI CD84 ANTIBODIES, COMPOSITIONS COMPRISING SAME AND USES THEREOF Public/Granted day:2017-09-14
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