Invention Grant
- Patent Title: Optimised heavy chain and light chain signal peptides for the production of recombinant antibody therapeutics
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Application No.: US14435094Application Date: 2013-08-21
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Publication No.: US10066019B2Publication Date: 2018-09-04
- Inventor: Zhiwei Song
- Applicant: Agency for Science, Technology and Research
- Applicant Address: SG Singapore
- Assignee: Agency for Science, Technology and Research
- Current Assignee: Agency for Science, Technology and Research
- Current Assignee Address: SG Singapore
- Agency: Schwegman Lundberg & Woessner, P.A.
- Priority: SG201207629 20121012
- International Application: PCT/SG2013/000360 WO 20130821
- International Announcement: WO2014/058389 WO 20140417
- Main IPC: C07K16/22
- IPC: C07K16/22 ; C07K16/32 ; C07K16/28 ; C12N15/63 ; C07K16/24 ; C07K16/30
Abstract:
Antibodies of interest comprising a heavy chain signal peptide and/or a light chain signal peptide or combination thereof and compositions are described. The method of determining the signal peptide including creating data set of antibodies signal peptides, clustering, selecting and creating recombinant antibodies for enhanced expression and secretion are described.
Public/Granted literature
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