Invention Grant
- Patent Title: Chimeric small molecules for the recruitment of antibodies to cancer cells
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Application No.: US15083025Application Date: 2016-03-28
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Publication No.: US10066026B2Publication Date: 2018-09-04
- Inventor: David Spiegel , Ryan Murelli , Andrew Zhang
- Applicant: YALE UNIVERSITY
- Applicant Address: US CT New Haven
- Assignee: YALE UNIVERSITY
- Current Assignee: YALE UNIVERSITY
- Current Assignee Address: US CT New Haven
- Agent Henry D. Coleman; R. Neil Sudol
- Main IPC: C07K16/44
- IPC: C07K16/44 ; A61K9/00 ; A61K45/06 ; A61K47/48 ; C07K16/30 ; A61K31/4192 ; C07D249/04
Abstract:
The present invention relates to chimeric chemical compounds which are used to recruit antibodies to cancer cells, in particular, prostate cancer cells or metastasized prostate cancer cells. The compounds according to the present invention comprise an antibody binding terminus (ABT) moiety covalently bonded to a cell binding terminus (CBT) through a linker and optionally, a connector molecule.
Public/Granted literature
- US20160347863A1 CHIMERIC SMALL MOLECULES FOR THE RECRUITMENT OF ANTIBODIES TO CANCER CELLS Public/Granted day:2016-12-01
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