Invention Grant
- Patent Title: Compositions of active WNT protein
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Application No.: US15637903Application Date: 2017-06-29
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Publication No.: US10066206B2Publication Date: 2018-09-04
- Inventor: Roeland Nusse , Karl H. Willert
- Applicant: The Board of Trustees of the Leland Stanford Junior University
- Applicant Address: US CA Stanford
- Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee: The Board of Trustees of the Leland Stanford Junior University
- Current Assignee Address: US CA Stanford
- Agency: Bozivevic, Field & Francis LLP
- Agent Pamela J. Sherwood
- Main IPC: C12N5/074
- IPC: C12N5/074 ; A61K38/17 ; C07K14/47 ; C07K14/575 ; A61K38/16 ; C12N5/0789
Abstract:
Compositions of purified biologically active Wnt proteins are provided. Wnt proteins are found to be hydrophobic and post-translationally modified by addition of a lipid moiety at a conserved cysteine residue. Methods for isolation of Wnt utilize detergents that maintain the solubility of the modified protein.
Public/Granted literature
- US20180002661A1 COMPOSITIONS OF ACTIVE WNT PROTEIN Public/Granted day:2018-01-04
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