Invention Grant
- Patent Title: Compositions and methods for enhancing virus replication
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Application No.: US14898083Application Date: 2014-06-16
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Publication No.: US10066214B2Publication Date: 2018-09-04
- Inventor: Carolina Solange Ilkow , Fabrice Le Boeuf , John Cameron Bell , Jean-Simon Diallo , Rozanne Arulanandam
- Applicant: OTTAWA HOSPITAL RESEARCH INSTITUTE
- Applicant Address: CA Toronto
- Assignee: Turnstone Limited Partnership
- Current Assignee: Turnstone Limited Partnership
- Current Assignee Address: CA Toronto
- Agency: Borden Ladner Gervais LLP
- Agent David A. Nauman
- International Application: PCT/CA2014/050564 WO 20140616
- International Announcement: WO2014/198003 WO 20141218
- Main IPC: A61K39/00
- IPC: A61K39/00 ; A61K39/12 ; A61K39/285 ; A61K48/00 ; A01N63/00 ; C12N7/00 ; A61K35/76 ; C07K14/50 ; A61K38/17 ; A61K38/18 ; A61K35/766 ; A61K35/768
Abstract:
Described herein is a method of enhancing virus replication in permissive cells that express a receptor to FGF2 protein. The method includes administering FGF2 protein or a functional variant thereof and the virus to the permissive cells. An oncolytic virus having a genome that includes an open reading frame that encodes FGF2 protein or a functional variant thereof is also described.
Public/Granted literature
- US20160130563A1 COMPOSITIONS AND METHODS FOR ENHANCING VIRUS REPLICATION Public/Granted day:2016-05-12
Information query
