Invention Grant
- Patent Title: Nucleic acids useful for integrating into and gene expression in hyperthermophilic acidophilic Archaea
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Application No.: US14646673Application Date: 2013-11-21
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Publication No.: US10066223B2Publication Date: 2018-09-04
- Inventor: Steven M. Yannone , Adam Barnebey
- Applicant: The Regents of the University of California
- Applicant Address: US CA Oakland
- Assignee: The Regents of the University of California
- Current Assignee: The Regents of the University of California
- Current Assignee Address: US CA Oakland
- Agency: Kilpatrick Townsend & Stockton LLP
- International Application: PCT/US2013/071328 WO 20131121
- International Announcement: WO2014/081973 WO 20140530
- Main IPC: C12N15/74
- IPC: C12N15/74 ; C12N9/42
Abstract:
The present invention provides for a novel recombinant or isolated nucleic acid useful for integrating or being maintained in an Archaea or acidophilic hyperthermophilic eubacteria. The nucleic acid encodes a nucleotide sequence that is capable of stably integrating into the chromosome of a host cell, or being maintained as an extrachromosomal element in a host cell, that is an Archea, and a nucleotide sequence of interest. The present invention also provides for an Archaea host cell comprising the nucleic acid stably integrated into the chromosome or maintained episomally in the host cell, and a method of expressing the nucleotide sequence of interest in the host cell and/or directing glycosylation, multimerization, and/or membrane association or integration.
Public/Granted literature
- US20150291948A1 NUCLEIC ACIDS USEFUL FOR INTEGRATING INTO AND GENE EXPRESSION IN HYPERTHERMOPHILIC ACIDOPHILIC ARCHAEA Public/Granted day:2015-10-15
Information query
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