Invention Grant
- Patent Title: Microbial production of 3-hydroxypropionic acid
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Application No.: US14896897Application Date: 2014-06-12
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Publication No.: US10066245B2Publication Date: 2018-09-04
- Inventor: Niels Bjerg Jensen , Irina Borodina , Yun Chen , Jerome Maury , Kanchana Rueksomtawin Kildegaard , Jochen Förster , Jens Nielsen
- Applicant: TECHNICAL UNIVERSITY OF DENMARK
- Applicant Address: DK Kgs. Lyngby
- Assignee: TECHNICAL UNIVERSITY OF DENMARK
- Current Assignee: TECHNICAL UNIVERSITY OF DENMARK
- Current Assignee Address: DK Kgs. Lyngby
- Agency: Pillsbury Winthrop Shaw Pittman LLP
- Priority: EP13172149 20130614
- International Application: PCT/EP2014/062246 WO 20140612
- International Announcement: WO2014/198831 WO 20141218
- Main IPC: C12N1/19
- IPC: C12N1/19 ; C12P7/42 ; C12N9/04 ; C12N9/02 ; C12N9/00 ; C12N15/52 ; C12N15/81
Abstract:
A yeast cell having a reduced level of activity of NAD dependent glyceraldehyde-3-phosphate dehydrogenase (GAPDH) has at least one exogenous gene encoding NADP dependent GAPDH and/or has up-regulation of at least one endogenous gene expressing NADP dependent GAPDH, wherein combined expression of the enzymes NADP dependent GAPDH, PDC, ALD, ACS, ACC* and MCR in said host cell increases metabolic flux towards 3-HP via malonyl-CoA compared to an otherwise similar yeast cell lacking said genetic modification.
Public/Granted literature
- US20160138056A1 MICROBIAL PRODUCTION OF 3-HYDROXYPROPIONIC ACID Public/Granted day:2016-05-19
Information query
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