Invention Grant
- Patent Title: Yeast cells having NADP(H)-dependent reductive TCA pathway from pyruvate to succinate
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Application No.: US14416631Application Date: 2013-07-25
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Publication No.: US10066246B2Publication Date: 2018-09-04
- Inventor: Brian J. Rush , Kevin T. Watts , Vernon L. McIntosh , Arlene M. Fosmer , Gregory M. Poynter , Thomas W. McMullin
- Applicant: CARGILL INCORPORATED , BIOAMBER S.A.S.
- Applicant Address: US MN Wayzata
- Assignee: CARGILL, INCORPORATED
- Current Assignee: CARGILL, INCORPORATED
- Current Assignee Address: US MN Wayzata
- International Application: PCT/US2013/052066 WO 20130725
- International Announcement: WO2014/018755 WO 20140130
- Main IPC: C12N15/52
- IPC: C12N15/52 ; C12P7/46 ; C07K14/395 ; C12N9/04 ; C12N9/02 ; C12N9/88 ; C12N9/92 ; C12N9/00
Abstract:
Recombinant yeast cells contain a reductive TCA pathway from phosphoenolpyruvate or pyruvate to succinate. At least one metabolic step in the pathway includes a reaction of NADPH to produce NADP+. The yeast cell contains at least one exogenous NADPH-dependent gene in the pathway from phosphoenolpyruvate or pyruvate to succinate, preferably an NADPH-dependent malate dehydrogensase or fumarate reducase gene (or both).
Public/Granted literature
- US20150176038A1 Yeast Cells Having NADP(H)-Dependent Reductive TCA Pathway from Pyruvate to Succinate Public/Granted day:2015-06-25
Information query
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