A method for operating an internal combustion engine, in particular a gas engine having at least two cylinders, includes acquiring a cylinder-specific first cylinder signal (pmax, E) from each cylinder. At least one combustion parameter (Q, Z) of the corresponding cylinder is controlled as a function of the first cylinder signal (pmax, E), and a cylinder-specific reference cylinder value (pmax′, E′) is set for the first cylinder signal (pmax, E) for each cylinder. The at least one combustion parameter (Q, Z) of the cylinder is adjusted as a function of the deviation of the first cylinder signal (pmax, E) from the reference cylinder value (pmax′, E′), and the first cylinder signal (pmax, E) tracks the reference cylinder value (pmax′, E′).