A stone slab with a light source and a manufacturing process thereof are disclosed. The stone slab includes a transparent composite plate. The composite plate includes a stone panel, a light guide plate, and a honeycomb plate laminated from top to bottom. A water-molecule-activated protective film is provided on an upper surface and a lower surface of the light guide plate respectively. The water-molecule-activated protective film on the upper surface of the light guide plate is bonded to the stone panel. The water-molecule-activated protective film on the lower surface of the light guide plate is bonded to the honeycomb plate by using an adhesive. The water-molecule-activated protective film can be used to bond the light guide plate. Moreover, the adhesive on another side of the water-molecule-activated protective film does not directly contact the light guide plate and avoids a problem that a lighting effect is impaired.