Illustrative embodiments of the present invention are directed to methods and systems for receiving physiological data of occupants of a building and using the information to control or regulate a controllable setpoint of a climate-control system for the building. The system may operatively interface with biofeedback sensors including wearable sensors and mountable sensors placed within a controlled space within the building. The system may adjust the controllable setpoint of the climate-control system based on a comfort metric associated with at least one of the occupant of the building, the comfort metric derived from the biofeedback data.