A method of operating an I2C slave having an I2C clock pin and an I2C data pin is disclosed. The method includes (a) receiving a command via the I2C clock pin and the I2C data pin, (b) driving the I2C data pin to logic low for a first duration, (c) not driving the I2C data pin to logic low for a second duration, and (d) repeatingly alternating (b) and (c) until a termination event occurs. (b) and (c) are not synchronized to transitions of the I2C clock pin. Other methods and systems are disclosed.