A method and a user equipment (UE) for generating a reference signal sequence in a wireless communication system are discussed. The method according to an embodiment includes receiving a cell-specific sequence hopping parameter from a base station. The cell-specific sequence hopping parameter is used to enable a sequence hopping for a plurality of UEs in a cell if a cell-specific group hopping parameter is used to disable a group hopping for the plurality of UEs in the cell. The method includes receiving a UE-specific sequence group hopping (SGH) parameter, specified to the UE, from the base station. The UE-specific SGH parameter is used to disable the sequence hopping, enabled by the cell-specific sequence hopping parameter. The method includes generating the reference signal sequence based on a base sequence number within a base sequence group. The base sequence number within the base sequence group is determined by the UE-specific SGH parameter.