The present invention provides a simple and efficient cipher and key generation and selection capability from a predetermined, randomly changing, fixed size matrix (N) of ciphers and keys resulting in a very high-order approximation (Nr,c→∞) of a true One Time Pad for encryption solutions such as the CipherLoc Polymorphic Key Progression Algorithmic Cipher Engine. The ciphers are randomly selected from a pool of user supplied ciphers, FIPS 140-2 or other certified ciphers and the keys are produced from various methods for generating a key that includes reading a data stream from a network or a Cryptographic Pseudo Random Number Generator (CPRNG)/Pseudo Random Number Generator (PRNG) or a Predetermined Cryptographic Key Generator (PCKG) or any combination of all. Ciphers and generated keys are randomly paired and stored in a volatile matrix for use by an encryption solution. When used with the CipherLoc Polymorphic Key Progression Algorithmic (PKPA) Cipher Engine, the OTP Matrix is a method of accomplishing the generation of the key and the selection and association of a suitable cipher with that key, for each sub-message, such that not only key space and equivalent keys (isomorphs) become important, but, the number of keys are also important, thus increasing the effective size of the key space in each sub-message.