Described are filter cartridges comprising: a cartridge body and a filter media; a stem extending from the cartridge body, the stem having an inlet opening, an outlet opening, and a stem face that comprises a first valve driving surface and a second valve driving surface; and at least one lug attached to either the filter body or the stem having a leading engagement edge. The filter cartridges are suitable for translational insertion and rotational engagement of a manifold, wherein upon translation insertion, a valve engagement member of the filter cartridge engages a portion of a valve body of a manifold valve; during a first stage rotation, one or more retaining members of the filter cartridge engage a manifold cam of a manifold; and during a second stage rotation, the valve engagement member imparts rotational movement to the valve body. Systems and methods incorporating the filter cartridges are disclosed.